Cargando…

Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

The BubR1/Bub3 complex is an important regulator of chromosome segregation as it facilitates proper kinetochore–microtubule interactions and is also an essential component of the spindle assembly checkpoint (SAC). Whether BubR1/Bub3 localization to kinetochores in human cells stimulates SAC signalli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Gang, Mendez, Blanca Lopez, Sedgwick, Garry G., Nilsson, Jakob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963475/ https://www.ncbi.nlm.nih.gov/pubmed/27457023 http://dx.doi.org/10.1038/ncomms12256

Ejemplares similares

Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint
por: Zhang, Gang, et al.
Publicado: (2015)

BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling
por: Banerjee, Anand, et al.
Publicado: (2022)

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation
por: Vleugel, Mathijs, et al.
Publicado: (2013)

Aurora B Tension Sensing Mechanisms in the Kinetochore Ensure Accurate Chromosome Segregation
por: McVey, Shelby L., et al.
Publicado: (2021)

Bub3–BubR1-dependent sequestration of Cdc20(Fizzy) at DNA breaks facilitates the correct segregation of broken chromosomes
por: Derive, Nicolas, et al.
Publicado: (2015)

Bub1 regulates chromosome segregation in a kinetochore-independent manner
por: Klebig, Christiane, et al.
Publicado: (2009)

The architecture of the BubR1 tetratricopeptide tandem repeat defines a protein motif underlying mitotic checkpoint-kinetochore communication
por: Bolanos-Garcia, Victor M., et al.
Publicado: (2012)

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit
por: Huang, Haomin, et al.
Publicado: (2008)

How Chromosome Mis-Segregation Leads to Cancer: Lessons from BubR1 Mouse Models
por: Lee, Hyunsook
Publicado: (2014)

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
por: Ditchfield, Claire, et al.
Publicado: (2003)

Coupling of Cdc20 inhibition and activation by BubR1
por: Hein, Jamin B., et al.
Publicado: (2021)

BubR1 and brain aging
por: Hussaini, Syed Mohammed Qasim, et al.
Publicado: (2017)

Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition
por: D'Arcy, Sheena, et al.
Publicado: (2010)

BubR1 checks in with CENP-E
por: LeBrasseur, Nicole
Publicado: (2003)

BubR1 shows self-control
por: Short, Ben
Publicado: (2012)

Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B
por: Buttrick, Graham J., et al.
Publicado: (2011)

Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation
por: Suhandynata, Raymond T., et al.
Publicado: (2019)

BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1
por: Chen, Rey-Huei
Publicado: (2002)

BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment
por: Zhang, Jiayin, et al.
Publicado: (2007)

BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment
por: Zhang, Jiayin, et al.
Publicado: (2007)

A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1
por: Duranteau, Marie, et al.
Publicado: (2016)

Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1
por: Lagirand-Cantaloube, Julie, et al.
Publicado: (2017)

CENP-E–dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint
por: Guo, Yige, et al.
Publicado: (2012)

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment
por: Legal, Thibault, et al.
Publicado: (2020)

Separating the spindle, checkpoint, and timer functions of BubR1
por: Rahmani, Zohra, et al.
Publicado: (2009)

BUB1 and BUBR1: multifaceted kinases of the cell cycle
por: Bolanos-Garcia, Victor M., et al.
Publicado: (2011)

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint
por: Overlack, Katharina, et al.
Publicado: (2015)

Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability
por: Almacellas, Eugènia, et al.
Publicado: (2020)

Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis
por: Lee, Yoo-Kyung, et al.
Publicado: (2014)

Distinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation
por: Cairo, Gisela, et al.
Publicado: (2023)

Distinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation
por: Cairo, Gisela, et al.
Publicado: (2023)

Drosophila CENP-A Mutations Cause a BubR1- Dependent Early Mitotic Delay without Normal Localization of Kinetochore Components
por: Blower, Michael D, et al.
Publicado: (2006)

BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling
por: Overlack, Katharina, et al.
Publicado: (2017)

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma
por: Chen, Honglin, et al.
Publicado: (2015)

The progeroid gene BubR1 regulates axon myelination and motor function
por: Choi, Chan-Il, et al.
Publicado: (2016)

BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice
por: Cho, Chang Hoon, et al.
Publicado: (2018)

Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
por: Yang, Zhongxi, et al.
Publicado: (2017)

P53 independent pathogenic mechanisms contribute to BubR1 microcephaly
por: Sterling, Noelle A., et al.
Publicado: (2023)

Differential requirement for Bub1 and Bub3 in regulation of meiotic versus mitotic chromosome segregation
por: Cairo, Gisela, et al.
Publicado: (2020)

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation
por: Mo, Fei, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gi0fepotgo65fnc32f934rf6hu