Cargando…

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

Polymyxin B and colistin are exclusively active against Gram-negative pathogens and have been used in the clinic as a last-line therapy. In this study, we investigated the antimicrobial activity of a novel polymyxin, FADDI-019, against Staphylococcus aureus. MIC and time-kill assays were employed to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Jinxin, Cheah, Soon-Ee, Roberts, Kade D., Nation, Roger L., Thompson, Philip E., Velkov, Tony, Du, Zongjun, Johnson, Matthew D., Li, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963539/ https://www.ncbi.nlm.nih.gov/pubmed/27471750 http://dx.doi.org/10.1128/mSphere.00119-16

Ejemplares similares

Design and Evaluation of Novel Polymyxin Fluorescent Probes
por: Yun, Bo, et al.
Publicado: (2017)

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
por: Velkov, Tony, et al.
Publicado: (2014)

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
por: Deris, Zakuan Z., et al.
Publicado: (2013)

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells
por: Li, Mengyao, et al.
Publicado: (2023)

707. QPX9003: Pharmacology of a Novel Polymyxin in Mice and Rats
por: Sabet, Mojgan, et al.
Publicado: (2019)

Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria
por: Deris, Zakuan Z., et al.
Publicado: (2014)

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii
por: Tran, Thien B., et al.
Publicado: (2015)

Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens
por: Cheah, Soon-Ee, et al.
Publicado: (2016)

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii
por: Mahamad Maifiah, Mohd Hafidz, et al.
Publicado: (2016)

Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach
por: Azad, Mohammad A. K., et al.
Publicado: (2015)

Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling
por: Zhu, Yan, et al.
Publicado: (2019)

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules
por: Schneider-Futschik, Elena K., et al.
Publicado: (2018)

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii
por: Jiang, Xukai, et al.
Publicado: (2021)

Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa
por: Mahamad Maifiah, Mohd Hafidz, et al.
Publicado: (2022)

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens
por: Tran, Thien B., et al.
Publicado: (2018)

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study
por: Tran, Thien B., et al.
Publicado: (2018)

Rescuing the Last-Line Polymyxins: Achievements and Challenges
por: Nang, Sue C., et al.
Publicado: (2021)

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa
por: Han, Mei-Ling, et al.
Publicado: (2019)

Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells
por: Li, Mengyao, et al.
Publicado: (2022)

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa
por: Zhu, Yan, et al.
Publicado: (2018)

Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant Klebsiella pneumoniae
por: Hussein, Maytham, et al.
Publicado: (2022)

Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins
por: Vestergaard, Martin, et al.
Publicado: (2017)

Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant Pseudomonas aeruginosa and Minimize Biofilm Formation
por: Wickremasinghe, Hasini, et al.
Publicado: (2021)

Coarse-grained simulations uncover Gram-negative bacterial defense against polymyxins by the outer membrane
por: Jiang, Xukai, et al.
Publicado: (2021)

Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae
por: Lu, Jing, et al.
Publicado: (2023)

Polymyxins–Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment
por: Dai, Chongshan, et al.
Publicado: (2020)

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa
por: Lin, Yu-Wei, et al.
Publicado: (2019)

Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against Acinetobacter baumannii: A Metabolomic Study
por: Hussein, Maytham, et al.
Publicado: (2022)

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity
por: Lu, Jing, et al.
Publicado: (2022)

Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria
por: Bergen, Phillip J., et al.
Publicado: (2015)

Simeprevir restores the anti-Staphylococcus activity of polymyxins
por: Wu, Yuan, et al.
Publicado: (2023)

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study
por: Hussein, Maytham, et al.
Publicado: (2020)

Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations
por: Koh Jing Jie, Augustine, et al.
Publicado: (2022)

Polymyxin Acute Kidney Injury: Dosing and Other Strategies to Reduce Toxicity
por: Nation, Roger L., et al.
Publicado: (2019)

Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae
por: Hanafin, Patrick O., et al.
Publicado: (2023)

Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain
por: Hussein, Maytham, et al.
Publicado: (2022)

Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm
por: Lakota, Elizabeth A., et al.
Publicado: (2018)

Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae
por: Hussein, Maytham, et al.
Publicado: (2023)

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates
por: Jasim, Raad, et al.
Publicado: (2018)

Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages
por: Kho, Zhi Ying, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_b9pdjnrcgjvhvm2m818pk4i1ar