Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication

Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from endosomal lumen into the host cell cytosol. Here...

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Detalles Bibliográficos
Autores principales: Schnell, Leonie, Mittler, Ann-Katrin, Mattarei, Andrea, Tehran, Domenico Azarnia, Montecucco, Cesare, Barth, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963853/
https://www.ncbi.nlm.nih.gov/pubmed/27428999
http://dx.doi.org/10.3390/toxins8070221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963853/
https://www.ncbi.nlm.nih.gov/pubmed/27428999
http://dx.doi.org/10.3390/toxins8070221

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