PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma

BACKGROUND: Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proliferation and cell migration. However, it is not clear whether advanced UC tu...

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Detalles Bibliográficos
Autores principales: Ross, R. L., McPherson, H. R., Kettlewell, L., Shnyder, S. D., Hurst, C. D., Alder, O., Knowles, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964013/
https://www.ncbi.nlm.nih.gov/pubmed/27465249
http://dx.doi.org/10.1186/s12885-016-2570-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964013/
https://www.ncbi.nlm.nih.gov/pubmed/27465249
http://dx.doi.org/10.1186/s12885-016-2570-0

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