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PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma

BACKGROUND: Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proliferation and cell migration. However, it is not clear whether advanced UC tu...

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Detalles Bibliográficos
Autores principales:	Ross, R. L., McPherson, H. R., Kettlewell, L., Shnyder, S. D., Hurst, C. D., Alder, O., Knowles, M. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964013/ https://www.ncbi.nlm.nih.gov/pubmed/27465249 http://dx.doi.org/10.1186/s12885-016-2570-0

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