Cargando…

C-terminal domain of p42 Ebp1 is essential for down regulation of p85 subunit of PI3K, inhibiting tumor growth

Potential tumor suppressor p42, ErbB3-binding protein 1 (EBP1) inhibits phosphoinositide 3-kinase (PI3K) activity reducing the p85 regulatory subunit. In this study, we demonstrated that overexpression of p42 promoted not only a reduction of wild type of p85 subunit but also oncogenic mutant forms o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwang, Inwoo, Kim, Chung Kwon, Ko, Hyo Rim, Park, Kye Won, Cho, Sung-Woo, Ahn, Jee-Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964336/ https://www.ncbi.nlm.nih.gov/pubmed/27464702 http://dx.doi.org/10.1038/srep30626

Ejemplares similares

The roles of multifunctional protein ErbB3 binding protein 1 (EBP1) isoforms from development to disease
por: Hwang, Inwoo, et al.
Publicado: (2020)

P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP
por: Ko, H R, et al.
Publicado: (2014)

Neuron-specific expression of p48 Ebp1 during murine brain development and its contribution to CNS axon regeneration
por: Ko, Hyo Rim, et al.
Publicado: (2017)

P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer
por: Ko, Hyo Rim, et al.
Publicado: (2015)

EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development
por: Kim, Byeong-Seong, et al.
Publicado: (2021)

Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1(+/−) Mice
por: Hwang, Inwoo, et al.
Publicado: (2020)

The regulatory subunits of PI3K, p85α and p85β, differentially affect BRD7-mediated regulation of insulin signaling
por: Lee, Junsik M, et al.
Publicado: (2021)

PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits
por: Wang, Qi, et al.
Publicado: (2020)

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β
por: Ito, Yoshihiro, et al.
Publicado: (2017)

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K
por: Conley, Mary Ellen, et al.
Publicado: (2012)

A study of two-pion states centrally produced in the reactions pi+p --> pi+(pi+pi-)p and pp --> p(pi+pi-)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1985)

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors
por: Tsolakos, N., et al.
Publicado: (2018)

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
por: Luo, Ji, et al.
Publicado: (2005)

Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation
por: Jin, Eun-Ju, et al.
Publicado: (2018)

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit
por: Shriver, Marey, et al.
Publicado: (2016)

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit
por: Neal, Christopher L., et al.
Publicado: (2011)

Study of the K+K-pi+pi- system centrally produced in the reactions pi+p --> pi+(K+K-pi+pi-)p and pp --> p(K+K-pi+pi-)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1986)

Study of the $\pi^{+}\pi^{+}\pi^{-}\pi^{-}$ system centrally produced by incident $\pi^{+}$ and p beams at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1989)

YC-1 Antagonizes Wnt/β-Catenin Signaling Through the EBP1 p42 Isoform in Hepatocellular Carcinoma
por: Wu, Ju-Yun, et al.
Publicado: (2019)

Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPα) p42 versus p30 may contribute in part, to aberrant C/EBPα activity in acute leukemias
por: Hankey, William, et al.
Publicado: (2011)

$\pi ^{+}-p$ and $p-p$ elastic scattering at 8.5, 12.4 and 18.4 GeV/c
por: Harting, D, et al.
Publicado: (1965)

The p85 Regulatory Subunit of PI3K Mediates cAMP-PKA and Insulin Biological Effects on MCF-7 Cell Growth and Motility
por: Di Zazzo, E., et al.
Publicado: (2014)

PI3K p85α Subunit-deficient Macrophages Protect Mice from Acute Colitis due to the Enhancement of IL-10 Production
por: Hayashi, Shusaku, et al.
Publicado: (2017)

Marek’s Disease Virus Activates the PI3K/Akt Pathway Through Interaction of Its Protein Meq With the P85 Subunit of PI3K to Promote Viral Replication
por: Li, Huimin, et al.
Publicado: (2018)

A study of meson systems centrally produced in the reactions pi+p --> pi+(X0)p and pp --> p(X0)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1985)

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration
por: Ko, Hyo Rim, et al.
Publicado: (2016)

Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42
por: Wang, Qin, et al.
Publicado: (2010)

Study of mesons produced centrally in the reaction pp --> pp + X0 and pi+p --> pi+p + X0 at 85 GeV/c
por: Palano, A, et al.
Publicado: (1983)

Proposal to the SPSC: study of $\pi^{-}$p interactions at 85 GeV/c leading to $\kappa^{+}
por: Jackson, J N, et al.
Publicado: (1979)

Backward $\pi p $ elastic scattering at 2.85 and 3.30 GeV/c
por: Baker, W F, et al.
Publicado: (1967)

Class I(A) PI3Kinase Regulatory Subunit, p85α, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes
por: Krishnan, Subha, et al.
Publicado: (2012)

Insight into the PTEN – p85α interaction and lipid binding properties of the p85α BH domain
por: Marshall, Jeremy D.S., et al.
Publicado: (2018)

Partial Wave Analysis Of The Low Mass (pi+ Pi- P) System Produced In K- P Interactions At 4.2-gev/c
por: Heinen, P M, et al.
Publicado: (1977)

Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin
por: Ni, Duan, et al.
Publicado: (2018)

Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling
por: Ko, Hyo Rim, et al.
Publicado: (2018)

Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium
por: Cheung, Lydia WT, et al.
Publicado: (2015)

Observation of double phi-meson production in the central region for the reactions pi+p --> pi+(K+K+K-K-)p and pp --> p(K+K+K-K-)p at 85 GeV
por: Armstrong, T A, et al.
Publicado: (1986)

The Effect of Proline cis-trans Isomerization on the Folding of the C-Terminal SH2 Domain from p85
por: Troilo, Francesca, et al.
Publicado: (2019)

Homodimer-mediated phosphorylation of C/EBPα-p42 S16 modulates acute myeloid leukaemia differentiation through liquid-liquid phase separation
por: Wang, Dongmei, et al.
Publicado: (2023)

P. berghei Telomerase Subunit TERT is Essential for Parasite Survival
por: Religa, Agnieszka A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_c90vn9alnmhgt97qec3mqs38j2