Cargando…

Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position

The first Pt(IV) derivative of oxaliplatin carrying a ligand for TSPO (the 18-kDa mitochondrial translocator protein) has been developed. The expression of the translocator protein in the brain and liver of healthy humans is usually low, oppositely to steroid-synthesizing and rapidly proliferating t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Savino, Salvatore, Denora, Nunzio, Iacobazzi, Rosa Maria, Porcelli, Letizia, Azzariti, Amalia, Natile, Giovanni, Margiotta, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964386/ https://www.ncbi.nlm.nih.gov/pubmed/27347942 http://dx.doi.org/10.3390/ijms17071010

Ejemplares similares

New Oxaliplatin-Pyrophosphato Analogs with Improved In Vitro Cytotoxicity
por: Barbanente, Alessandra, et al.
Publicado: (2021)

Grape seed extracts modify the outcome of oxaliplatin in colon cancer cells by interfering with cellular mechanisms of drug cytotoxicity
por: Porcelli, Letizia, et al.
Publicado: (2017)

An Updated View of Translocator Protein (TSPO)
por: Denora, Nunzio, et al.
Publicado: (2017)

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
por: Nosova, Yulia N., et al.
Publicado: (2017)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action
por: Raveendran, Raji, et al.
Publicado: (2016)

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions
por: Savino, Salvatore, et al.
Publicado: (2018)

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand–Dextran Nanogels
por: Lopalco, Antonio, et al.
Publicado: (2018)

Pt(IV) Prodrugs with NSAIDs as Axial Ligands
por: Spector, Daniil, et al.
Publicado: (2021)

Potential predictive role of chemotherapy-induced changes of soluble CD40 ligand in untreated advanced pancreatic ductal adenocarcinoma
por: Azzariti, Amalia, et al.
Publicado: (2016)

Synthesis and Evaluation of Tricarbonyl (99m)Tc-Labeled 2-(4-Chloro)phenyl-imidazo[1,2-a]pyridine Analogs as Novel SPECT Imaging Radiotracer for TSPO-Rich Cancer
por: Choi, Ji Young, et al.
Publicado: (2016)

The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
por: Ailuno, Giorgia, et al.
Publicado: (2021)

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting
por: Fanizza, Elisabetta, et al.
Publicado: (2019)

Microfluidic-Assisted Preparation of Targeted pH-Responsive Polymeric Micelles Improves Gemcitabine Effectiveness in PDAC: In Vitro Insights
por: Iacobazzi, Rosa Maria, et al.
Publicado: (2021)

Hydroxy-Propil-β-Cyclodextrin Inclusion Complexes of two Biphenylnicotinamide Derivatives: Formulation and Anti-Proliferative Activity Evaluation in Pancreatic Cancer Cell Models
por: Iacobazzi, Rosa Maria, et al.
Publicado: (2020)

The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6-OHDA-Induced PC12 Cell Death as an In Vitro Model for Parkinson’s Disease
por: Monga, Sheelu, et al.
Publicado: (2021)

Efficaciousness of Low Affinity Compared to High Affinity TSPO Ligands in the Inhibition of Hypoxic Mitochondrial Cellular Damage Induced by Cobalt Chloride in Human Lung H1299 Cells
por: Zeineh, Nidal, et al.
Publicado: (2020)

Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance
por: Papadia, Paride, et al.
Publicado: (2020)

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
por: Thejer, Bashar M., et al.
Publicado: (2023)

Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration
por: Barbanente, Alessandra, et al.
Publicado: (2022)

The protective effect of the TSPO ligands 2,4-Di-Cl-MGV-1, CB86, and CB204 against LPS-induced M1 pro-inflammatory activation of microglia
por: Monga, Sheelu, et al.
Publicado: (2020)

Long Non-Coding RNA Landscape in Prostate Cancer Molecular Subtypes: A Feature Selection Approach
por: De Summa, Simona, et al.
Publicado: (2021)

The Role of Non-Coding RNAs as Prognostic Factor, Predictor of Drug Response or Resistance and Pharmacological Targets, in the Cutaneous Squamous Cell Carcinoma
por: Garofoli, Marianna, et al.
Publicado: (2020)

Radiosynthesis and characterization of [(18)F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism
por: Lee, Sang Hee, et al.
Publicado: (2021)

Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study
por: Argentiero, Antonella, et al.
Publicado: (2019)

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer
por: Porcelli, Letizia, et al.
Publicado: (2019)

Antitumor Trans Platinum DNA Adducts: NMR and HPLC Study of the Interaction Between a trans-Pt Iminoether Complex and the Deoxy Decamer d(CCTCGCTCTC)·d(GAGAGCGAGG)
por: Andersen, Bjørn, et al.
Publicado: (2000)

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands
por: Veenman, Leo, et al.
Publicado: (2016)

Barasertib: a novel approach for the treatment of metastatic melanoma
por: Azzariti, Amalia, et al.
Publicado: (2014)

Plasma-activated medium triggers cell death and the presentation of immune activating danger signals in melanoma and pancreatic cancer cells
por: Azzariti, Amalia, et al.
Publicado: (2019)

Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine
por: Shehadeh, Mona, et al.
Publicado: (2019)

TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
por: Lejri, Imane, et al.
Publicado: (2019)

Exploring the Microfluidic Production of Biomimetic Hybrid Nanoparticles and Their Pharmaceutical Applications
por: Fondaj, Dafina, et al.
Publicado: (2023)

Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma
por: Serratì, Simona, et al.
Publicado: (2020)

Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands
por: Li, Xuejiao, et al.
Publicado: (2018)

Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy
por: Porcelli, Letizia, et al.
Publicado: (2015)

Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling
por: Yasin, Nasra, et al.
Publicado: (2017)

Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma
por: Serratì, Simona, et al.
Publicado: (2022)

Fully Automated Synthesis of Novel TSPO PET Imaging Ligand [(18)F]Fluoroethyltemazepam
por: Fiorenza, Dario, et al.
Publicado: (2021)

A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring
por: Papadia, Paride, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_um9gmjrkcm8dgaojt6lvd735uo