The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis

Aging is one of the major pathologic factors associated with osteoarthritis (OA). Recently, numerous reports have demonstrated the impact of sirtuin-1 (Sirt1), which is the NAD-dependent deacetylase, on human aging. It has been demonstrated that Sirt1 induces osteogenic and chondrogenic differentiat...

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Detalles Bibliográficos
Autores principales: Terauchi, Koh, Kobayashi, Hajime, Yatabe, Kanaka, Yui, Naoko, Fujiya, Hiroto, Niki, Hisateru, Musha, Haruki, Yudoh, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964395/
https://www.ncbi.nlm.nih.gov/pubmed/27367673
http://dx.doi.org/10.3390/ijms17071019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964395/
https://www.ncbi.nlm.nih.gov/pubmed/27367673
http://dx.doi.org/10.3390/ijms17071019

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