Prodifferentiation Activity of Novel Vitamin D(2) Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells

1α,25-dihydroxyvitamin D(3) (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D(2) is less toxic than vitamin D(3) in animals. H...

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Detalles Bibliográficos
Autores principales: Nachliely, Matan, Sharony, Ehud, Bolla, Narasimha Rao, Kutner, Andrzej, Danilenko, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964444/
https://www.ncbi.nlm.nih.gov/pubmed/27399677
http://dx.doi.org/10.3390/ijms17071068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964444/
https://www.ncbi.nlm.nih.gov/pubmed/27399677
http://dx.doi.org/10.3390/ijms17071068

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