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Prodifferentiation Activity of Novel Vitamin D(2) Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells
1α,25-dihydroxyvitamin D(3) (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D(2) is less toxic than vitamin D(3) in animals. H...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964444/ https://www.ncbi.nlm.nih.gov/pubmed/27399677 http://dx.doi.org/10.3390/ijms17071068 |