Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1

A regulatory circuit that controls myeloid versus B lymphoid cell fate in hematopoietic progenitors has been proposed, in which a network of the transcription factors Egr1/2, Nab, Gfi1 and PU.1 forms the core element. Here we show that a direct link between Gfi1, the transcription factor E2A and its...

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Detalles Bibliográficos
Autores principales: Fraszczak, Jennifer, Helness, Anne, Chen, Riyan, Vadnais, Charles, Robert, François, Khandanpour, Cyrus, Möröy, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965025/
https://www.ncbi.nlm.nih.gov/pubmed/27467586
http://dx.doi.org/10.1371/journal.pone.0160344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965025/
https://www.ncbi.nlm.nih.gov/pubmed/27467586
http://dx.doi.org/10.1371/journal.pone.0160344

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