Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses

Although Plasmodium vivax relapses are classically associated with hypnozoite activation, it has been proposed that a proportion of these cases are due to primaquine (PQ) treatment failure caused by polymorphisms in cytochrome P-450 2D6 (CYP2D6). Here, we present evidence that CYP2D6 polymorphisms a...

Descripción completa

Detalles Bibliográficos
Autores principales: Silvino, Ana Carolina Rios, Costa, Gabriel Luiz, de Araújo, Flávia Carolina Faustino, Ascher, David Benjamin, Pires, Douglas Eduardo Valente, Fontes, Cor Jesus Fernandes, Carvalho, Luzia Helena, de Brito, Cristiana Ferreira Alves, Sousa, Tais Nobrega
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965052/
https://www.ncbi.nlm.nih.gov/pubmed/27467145
http://dx.doi.org/10.1371/journal.pone.0160172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965052/
https://www.ncbi.nlm.nih.gov/pubmed/27467145
http://dx.doi.org/10.1371/journal.pone.0160172

Ejemplares similares