Blockade of Extracellular High-Mobility Group Box 1 Attenuates Systemic Inflammation and Coagulation Abnormalities in Rats with Acute Traumatic Coagulopathy

BACKGROUND: As an extracellularly released mediator, high-mobility group box 1 (HMGB1) initiates sterile inflammation following severe trauma. Serum HMGB1 levels correlate well with acute traumatic coagulopathy (ATC) in trauma patients, which is independently associated with higher mortality. We inv...

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Detalles Bibliográficos
Autores principales: Xu, Lin, Zhao, Kun, Shen, Xiao, Fan, Xin-xin, Ding, Kai, Liu, Ren-min, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Animal Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965062/
https://www.ncbi.nlm.nih.gov/pubmed/27436061
http://dx.doi.org/10.12659/MSM.900018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965062/
https://www.ncbi.nlm.nih.gov/pubmed/27436061
http://dx.doi.org/10.12659/MSM.900018

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