Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT

The receptors tyrosine kinases (RTKs) for the colony stimulating factor-1, CSF-1R, and for the stem cell factor, SCFR or KIT, are important mediators of signal transduction. The abnormal function of these receptors, promoted by gain-of-function mutations, leads to their constitutive activation, asso...

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Detalles Bibliográficos
Autores principales: Da Silva Figueiredo Celestino Gomes, Priscila, Chauvot De Beauchêne, Isaure, Panel, Nicolas, Lopez, Sophie, De Sepulveda, Paulo, Geraldo Pascutti, Pedro, Solary, Eric, Tchertanov, Luba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965071/
https://www.ncbi.nlm.nih.gov/pubmed/27467080
http://dx.doi.org/10.1371/journal.pone.0160165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965071/
https://www.ncbi.nlm.nih.gov/pubmed/27467080
http://dx.doi.org/10.1371/journal.pone.0160165

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