Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation

Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition receptors (e.g. Toll-like rec...

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Detalles Bibliográficos
Autores principales: Samelko, Lauryn, Landgraeber, Stefan, McAllister, Kyron, Jacobs, Joshua, Hallab, Nadim James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965114/
https://www.ncbi.nlm.nih.gov/pubmed/27467577
http://dx.doi.org/10.1371/journal.pone.0160141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965114/
https://www.ncbi.nlm.nih.gov/pubmed/27467577
http://dx.doi.org/10.1371/journal.pone.0160141

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