Cargando…

Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells

BACKGROUND: Cytochrome P450 2C19 (CYP2C19) is an important drug-metabolizing enzyme (DME), which is responsible for the biotransformation of several kinds of drugs such as proton pump inhibitors, platelet aggregation inhibitors and antidepressants. Previous studies showed that Buchang NaoXinTong cap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Hong, Lou, Xiao-Ya, Wu, Xiao-Ying, Wang, Huan, Qu, Qiang, Tan, Shen-Lan, Ruan, Jun-Shan, Qu, Jian, Chen, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965156/ https://www.ncbi.nlm.nih.gov/pubmed/27467078 http://dx.doi.org/10.1371/journal.pone.0160285

Ejemplares similares

Systematical Identification of the Protective Effect of Danhong Injection and BuChang NaoXinTong Capsules on Transcription Factors in Cerebral Ischemia Mice Brain
por: Xu, Jing, et al.
Publicado: (2020)

A Metabonomics Investigation into the Therapeutic Effects of BuChang NaoXinTong Capsules on Reversing the Amino Acid-Protein Interaction Network of Cerebral Ischemia
por: Xu, Jing, et al.
Publicado: (2019)

NaoXinTong Inhibits the Development of Diabetic Retinopathy in db/db Mice
por: Liu, Mengyang, et al.
Publicado: (2015)

NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice
por: Yang, Shu, et al.
Publicado: (2018)

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells
por: Zhang, Jun, et al.
Publicado: (2013)

Novel plant inducers of PXR-dependent cytochrome P450 3A4 expression in HepG2 cells
por: Al-Dosari, Mohammed S., et al.
Publicado: (2018)

Proteomic Assessment of iTRAQ-Based NaoMaiTong in the Treatment of Ischemic Stroke in Rats
por: Li, Kening, et al.
Publicado: (2019)

Efficacy and Safety of NaoShuanTong Capsule in the Treatment of Ischemic Stroke: A Meta-Analysis
por: Zhang, Hanlai, et al.
Publicado: (2019)

Tian Wang Bu Xin Dan for Insomnia: A Systematic Review of Efficacy and Safety
por: Yang, Xi-qian, et al.
Publicado: (2019)

Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR
por: Yao, Na, et al.
Publicado: (2019)

A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia
por: Liu, Junguang, et al.
Publicado: (2022)

Effect of Pei Yuan Tong Nao capsules on cerebral infarction: A protocol for systematic review and meta-analysis
por: Chen, Wangkun, et al.
Publicado: (2022)

Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells
por: Iwado, Satoru, et al.
Publicado: (2021)

Inhibition of phase-1 biotransformation and cytostatic effects of diphenyleneiodonium on hepatoblastoma cell line HepG2 and a CYP3A4-overexpressing HepG2 cell clone
por: Schulz, Christian, et al.
Publicado: (2021)

Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1
por: Holownia, A., et al.
Publicado: (2013)

Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells
por: Nakamura, Kazuaki, et al.
Publicado: (2017)

Tong Luo Jiu Nao ameliorates Aβ(1–40)-induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
por: Shi, Zhe, et al.
Publicado: (2015)

Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells
por: Jiang, Qin, et al.
Publicado: (2017)

Generation and Characterization of CYP2E1-Overexpressing HepG2 Cells to Study the Role of CYP2E1 in Hepatic Hypoxia-Reoxygenation Injury
por: Alwadei, Nouf, et al.
Publicado: (2023)

Investigating the Pharmacological Mechanisms of SheXiang XinTongNing Against Coronary Heart Disease Based on Network Pharmacology and Experimental Evaluation
por: Jia, Li-ying, et al.
Publicado: (2021)

Metabolomics-Based Pharmacodynamic Analysis of Zhuang Yao Shuang Lu Tong Nao Granules in a Rat Model of Ischemic Cerebral Infarction
por: Zhai, Yang, et al.
Publicado: (2022)

Dual Effects of Ketoconazole cis-Enantiomers on CYP3A4 in Human Hepatocytes and HepG2 Cells
por: Novotná, Aneta, et al.
Publicado: (2014)

Knockdown of nucleophosmin induces S-phase arrest in HepG2 cells
por: Wang, Qing-Qing, et al.
Publicado: (2011)

Effects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome
por: Su, Ya-Nan, et al.
Publicado: (2023)

Artificial cells eavesdropping on HepG2 cells
por: Westensee, Isabella Nymann, et al.
Publicado: (2023)

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR
por: Duan, Ya-bin, et al.
Publicado: (2020)

The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells
por: Rosellini, Matteo, et al.
Publicado: (2023)

Protective effects of a compound herbal extract (Tong Xin Luo) on free fatty acid induced endothelial injury: Implications of antioxidant system
por: Zhang, Lin, et al.
Publicado: (2008)

Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis
por: Liu, Hong, et al.
Publicado: (2014)

Tubeimoside I induces autophagy in HepG2 cells by activating the AMP-activated protein kinase signaling pathway
por: Ruan, Chengxu, et al.
Publicado: (2020)

Comparison of Adjunctive Naoxintong versus Clopidogrel in Volunteers with the CYP2C19*2 Gene Mutation Accompanied with Qi Deficiency and Blood Stasis Constitution
por: Chen, Hui, et al.
Publicado: (2011)

Corrigendum: Effects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome
por: Su, Ya-Nan, et al.
Publicado: (2023)

TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK–STAT signaling pathway
por: Zhu, X, et al.
Publicado: (2016)

Anti-tumor effect of volatile oil from Houttuynia cordata Thunb. on HepG2 cells and HepG2 tumor-bearing mice
por: Yang, Linsong, et al.
Publicado: (2019)

DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability
por: Tanaka-yachi, Rieko, et al.
Publicado: (2022)

A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile
por: Bailey, Ian, et al.
Publicado: (2011)

Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus
por: Wang, Ling, et al.
Publicado: (2015)

Bu-Shen-Ning-Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4(+) T lymphocytes of ovariectomized mice
por: Zhang, Jia-Li, et al.
Publicado: (2018)

The Inhibition Effect of the Seaweed Polyphenol, 7-Phloro-Eckol from Ecklonia Cava on Alcohol-Induced Oxidative Stress in HepG2/CYP2E1 Cells
por: Lin, Liyuan, et al.
Publicado: (2021)

Specific DNA identification of Pheretima in the Naoxintong capsule
por: Zhu, Xiaoxiao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_k1arajhvbmgc2g0l7picn6homo