T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions

Immune responses often take place where nutrients and O(2) availability are limited. This has an impact on T cell metabolism and influences activation and effector functions. T cell proliferation and expansion are associated with increased consumption of glutamine which is needed in a number of meta...

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Detalles Bibliográficos
Autores principales: Sener, Zeynep, Cederkvist, Fritjof H., Volchenkov, Roman, Holen, Halvor L., Skålhegg, Bjørn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965213/
https://www.ncbi.nlm.nih.gov/pubmed/27467144
http://dx.doi.org/10.1371/journal.pone.0160291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965213/
https://www.ncbi.nlm.nih.gov/pubmed/27467144
http://dx.doi.org/10.1371/journal.pone.0160291

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