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UbFluor: a mechanism-based probe for HECT E3 ligases

Homologues to E6AP Carboxyl Terminus E3 ubiquitin ligases (HECT, ∼28 known) are genetically implicated in cancer, neurological, hypertensive, and autoimmune disorders, and are potential drug targets to treat these diseases. The major bottleneck in the field of HECT E3s is a lack of simple assays to...

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Detalles Bibliográficos
Autores principales: Krist, David T., Park, Sungjin, Boneh, Galyah H., Rice, Sarah E., Statsyuk, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965700/
https://www.ncbi.nlm.nih.gov/pubmed/27482366
http://dx.doi.org/10.1039/c6sc01167e