Evaluating the necessity of PCR duplicate removal from next-generation sequencing data and a comparison of approaches

BACKGROUND: Analyzing next-generation sequencing data is difficult because datasets are large, second generation sequencing platforms have high error rates, and because each position in the target genome (exome, transcriptome, etc.) is sequenced multiple times. Given these challenges, numerous bioin...

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Detalles Bibliográficos
Autores principales: Ebbert, Mark T. W., Wadsworth, Mark E., Staley, Lyndsay A., Hoyt, Kaitlyn L., Pickett, Brandon, Miller, Justin, Duce, John, Kauwe, John S. K., Ridge, Perry G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965708/
https://www.ncbi.nlm.nih.gov/pubmed/27454357
http://dx.doi.org/10.1186/s12859-016-1097-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965708/
https://www.ncbi.nlm.nih.gov/pubmed/27454357
http://dx.doi.org/10.1186/s12859-016-1097-3

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