Cargando…
Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach
Artemisinin resistance in Plasmodium falciparum threatens global efforts in the elimination or eradication of malaria. Several studies have associated mutations in the PfATP6 gene in conjunction with artemisinin resistance, but the underlying molecular mechanism of the resistance remains unexplored....
Autores principales: | N., Nagasundaram, C., George Priya Doss, Chakraborty, Chiranjib, V., Karthick, D., Thirumal Kumar, V., Balaji, R., Siva, Lu, Aiping, Ge, Zhang, Zhu, Hailong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965867/ https://www.ncbi.nlm.nih.gov/pubmed/27471101 http://dx.doi.org/10.1038/srep30106 |
Ejemplares similares
-
Status of potential PfATP6 molecular markers for artemisinin resistance in Suriname
por: Adhin, Malti R, et al.
Publicado: (2012) -
Optimization of
2,3-Dihydroquinazolinone-3-carboxamides
as Antimalarials Targeting PfATP4
por: Ashton, Trent D., et al.
Publicado: (2023) -
Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
por: Spillman, Natalie J., et al.
Publicado: (2013) -
Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies
por: N, Nagasundaram, et al.
Publicado: (2015) -
The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs
por: Spillman, Natalie Jane, et al.
Publicado: (2015)