Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment

BACKGROUND: Opiates such as morphine are the most powerful analgesics, but their protracted use is restrained by the development of tolerance to analgesic effects. Recent works suggest that tolerance to morphine might be due to its inability to promote mu opioid receptor endocytosis, and the co-inje...

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Detalles Bibliográficos
Autores principales: Posa, Luca, Accarie, Alison, Noble, Florence, Marie, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966270/
https://www.ncbi.nlm.nih.gov/pubmed/26390873
http://dx.doi.org/10.1093/ijnp/pyv108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966270/
https://www.ncbi.nlm.nih.gov/pubmed/26390873
http://dx.doi.org/10.1093/ijnp/pyv108

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