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Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment
BACKGROUND: Opiates such as morphine are the most powerful analgesics, but their protracted use is restrained by the development of tolerance to analgesic effects. Recent works suggest that tolerance to morphine might be due to its inability to promote mu opioid receptor endocytosis, and the co-inje...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966270/ https://www.ncbi.nlm.nih.gov/pubmed/26390873 http://dx.doi.org/10.1093/ijnp/pyv108 |