Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects

The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates many important cellular functions. The functional impact of deregulating the PIK3CA gene, encoding the p110α catalytic subunit of PI3K, is validated by frequent gain of function mutations in a range of human cancers. We generated a...

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Detalles Bibliográficos
Autores principales: Sheen, Mee Rie, Warner, Sandra L., Fields, Jennifer L., Conejo-Garcia, Jose R., Fiering, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966669/
https://www.ncbi.nlm.nih.gov/pubmed/27482546
http://dx.doi.org/10.1515/biol-2015-0048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966669/
https://www.ncbi.nlm.nih.gov/pubmed/27482546
http://dx.doi.org/10.1515/biol-2015-0048

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