Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution

BACKGROUND: Blocking mTOR (molecular target of rapamycin) by sirolimus has been shown to suppress cellular respiration. The bearing of this impaired cellular bioenergetics on the mode-of-action of mTOR inhibitors has yet to be illustrated. METHODS: This study investigated in vitro effects of several...

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Detalles Bibliográficos
Autores principales: Al-Hammadi, Suleiman, Almarzooqi, Saeeda, Albawardi, Alia, Souid, Abdul-Kader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966723/
https://www.ncbi.nlm.nih.gov/pubmed/27478685
http://dx.doi.org/10.1186/s40164-016-0044-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966723/
https://www.ncbi.nlm.nih.gov/pubmed/27478685
http://dx.doi.org/10.1186/s40164-016-0044-3

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