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Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution
BACKGROUND: Blocking mTOR (molecular target of rapamycin) by sirolimus has been shown to suppress cellular respiration. The bearing of this impaired cellular bioenergetics on the mode-of-action of mTOR inhibitors has yet to be illustrated. METHODS: This study investigated in vitro effects of several...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966723/ https://www.ncbi.nlm.nih.gov/pubmed/27478685 http://dx.doi.org/10.1186/s40164-016-0044-3 |