Development of purification processes for fully human bispecific antibodies based upon modification of protein A binding avidity

There is strong interest in the design of bispecific monoclonal antibodies (bsAbs) that can simultaneously bind 2 distinct targets or epitopes to achieve novel mechanisms of action and efficacy. Multiple bispecific formats have been proposed and are currently under development. Regeneron's bisp...

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Detalles Bibliográficos
Autores principales: Tustian, Andrew D., Endicott, Christine, Adams, Benjamin, Mattila, John, Bak, Hanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966828/
https://www.ncbi.nlm.nih.gov/pubmed/26963837
http://dx.doi.org/10.1080/19420862.2016.1160192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966828/
https://www.ncbi.nlm.nih.gov/pubmed/26963837
http://dx.doi.org/10.1080/19420862.2016.1160192

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