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Development of purification processes for fully human bispecific antibodies based upon modification of protein A binding avidity
There is strong interest in the design of bispecific monoclonal antibodies (bsAbs) that can simultaneously bind 2 distinct targets or epitopes to achieve novel mechanisms of action and efficacy. Multiple bispecific formats have been proposed and are currently under development. Regeneron's bisp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966828/ https://www.ncbi.nlm.nih.gov/pubmed/26963837 http://dx.doi.org/10.1080/19420862.2016.1160192 |