Length-independent structural similarities enrich the antibody CDR canonical class model

Complementarity-determining regions (CDRs) are antibody loops that make up the antigen binding site. Here, we show that all CDR types have structurally similar loops of different lengths. Based on these findings, we created length-independent canonical classes for the non-H3 CDRs. Our length variabl...

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Detalles Bibliográficos
Autores principales: Nowak, Jaroslaw, Baker, Terry, Georges, Guy, Kelm, Sebastian, Klostermann, Stefan, Shi, Jiye, Sridharan, Sudharsan, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966832/
https://www.ncbi.nlm.nih.gov/pubmed/26963563
http://dx.doi.org/10.1080/19420862.2016.1158370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966832/
https://www.ncbi.nlm.nih.gov/pubmed/26963563
http://dx.doi.org/10.1080/19420862.2016.1158370

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