Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage

A functional DNA damage response is essential for maintaining genome integrity in the presence of DNA double-strand breaks. It is mainly coordinated by the kinases ATM, ATR, and DNA-PKcs, which control the repair of broken DNA strands and relay the damage signal to the tumor suppressor p53 to induce...

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Detalles Bibliográficos
Autores principales: Finzel, Ana, Grybowski, Andrea, Strasen, Jette, Cristiano, Elena, Loewer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966978/
https://www.ncbi.nlm.nih.gov/pubmed/27280387
http://dx.doi.org/10.1091/mbc.E16-01-0032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966978/
https://www.ncbi.nlm.nih.gov/pubmed/27280387
http://dx.doi.org/10.1091/mbc.E16-01-0032

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