Hsp90 induces increased genomic instability toward DNA-damaging agents by tuning down RAD53 transcription

It is well documented that elevated body temperature causes tumors to regress upon radiotherapy. However, how hyperthermia induces DNA damage sensitivity is not clear. We show that a transient heat shock and particularly the concomitant induction of Hsp90 lead to increased genomic instability under...

Descripción completa

Detalles Bibliográficos
Autores principales: Khurana, Nidhi, Laskar, Shyamasree, Bhattacharyya, Mrinal K., Bhattacharyya, Sunanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966986/
https://www.ncbi.nlm.nih.gov/pubmed/27307581
http://dx.doi.org/10.1091/mbc.E15-12-0867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966986/
https://www.ncbi.nlm.nih.gov/pubmed/27307581
http://dx.doi.org/10.1091/mbc.E15-12-0867

Ejemplares similares