Analytic Validation of a Clinical-Grade PTEN Immunohistochemistry Assay in Prostate Cancer by Comparison to PTEN FISH

PTEN loss is a promising prognostic and predictive biomarker in prostate cancer. Because it occurs most commonly via PTEN gene deletion, we developed a clinical-grade, automated and inexpensive immunohistochemical assay to detect PTEN loss. We studied the sensitivity and specificity of PTEN immunohi...

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Detalles Bibliográficos
Autores principales: Lotan, Tamara L., Wei, Wei, Ludkovski, Olga, Morais, Carlos L., Guedes, Liana B., Jamaspishvili, Tamara, Lopez, Karen, Hawley, Sarah T., Feng, Ziding, Fazli, Ladan, Hurtado-Coll, Antonio, McKenney, Jesse K., Simko, Jeffrey, Carroll, Peter R., Gleave, Martin, Lin, Daniel W., Nelson, Peter S., Thompson, Ian M., True, Lawrence D., Brooks, James D., Lance, Raymond, Troyer, Dean, Squire, Jeremy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967011/
https://www.ncbi.nlm.nih.gov/pubmed/27174589
http://dx.doi.org/10.1038/modpathol.2016.88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967011/
https://www.ncbi.nlm.nih.gov/pubmed/27174589
http://dx.doi.org/10.1038/modpathol.2016.88

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