Cargando…

Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass

Estrogens are important regulators of bone mass and their effects are mainly mediated via estrogen receptor (ER)α. Central ERα exerts an inhibitory role on bone mass. ERα is highly expressed in the arcuate (ARC) and the ventromedial (VMN) nuclei in the hypothalamus. To test whether ERα in proopiomel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farman, H. H., Windahl, S. H., Westberg, L., Isaksson, H., Egecioglu, E., Schele, E., Ryberg, H., Jansson, J. O., Tuukkanen, J., Koskela, A., Xie, S. K., Hahner, L., Zehr, J., Clegg, D. J., Lagerquist, M. K., Ohlsson, C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967117/ https://www.ncbi.nlm.nih.gov/pubmed/27254004 http://dx.doi.org/10.1210/en.2016-1181

Ejemplares similares

The role of membrane ERα signaling in bone and other major estrogen responsive tissues
por: Gustafsson, K. L., et al.
Publicado: (2016)

Proopiomelanocortin (POMC) and psychodermatology
por: Millington, George W. M., et al.
Publicado: (2023)

Extra-nuclear effects of estrogen on cortical bone in males require ERαAF-1
por: Farman, H H, et al.
Publicado: (2017)

ERα expression in T lymphocytes is dispensable for estrogenic effects in bone
por: Gustafsson, K L, et al.
Publicado: (2018)

The role of proopiomelanocortin (POMC) neurones in feeding behaviour
por: Millington, George WM
Publicado: (2007)

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice
por: Horkeby, Karin, et al.
Publicado: (2022)

The Bone Sparing Effects of 2-Methoxyestradiol Are Mediated via Estrogen Receptor-α in Male Mice
por: Eriksson, Anna L., et al.
Publicado: (2016)

Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons
por: Santiago, Ammy M., et al.
Publicado: (2016)

SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice
por: Börjesson, Anna E., et al.
Publicado: (2016)

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency
por: Surbhi, et al.
Publicado: (2021)

Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity
por: Makimura, Hideo, et al.
Publicado: (2003)

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity
por: Yu, Hui, et al.
Publicado: (2020)

Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice
por: Alsina, Ramiro, et al.
Publicado: (2018)

Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
por: Jones, Graham L., et al.
Publicado: (2019)

DNA methylation and expression of proopiomelanocortin (POMC) gene in the hypothalamus of three‐week‐old chickens show sex‐specific differences
por: Rancourt, Rebecca C., et al.
Publicado: (2018)

SUN-744 Phosphorylation Site S122 in Estrogen Receptor α Has a Tissue-Dependent Role in Female Mice
por: Gustafsson, Karin L, et al.
Publicado: (2020)

The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis
por: Engdahl, Cecilia, et al.
Publicado: (2014)

Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive
por: Fabelo, Carolina, et al.
Publicado: (2018)

LBODP109 Astrocytes Affect The Metabolism Of Proopiomelanocortin (pomc) Neurons Through The Release Of Exosomes That Are Modified In A Fatty Acid Specific Manner
por: Collado-Pérez, Roberto, et al.
Publicado: (2022)

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
por: Varela, Luis, et al.
Publicado: (2017)

Pulsed administration for physiological estrogen replacement in mice
por: Corciulo, Carmen, et al.
Publicado: (2021)

Lactate activates hypothalamic POMC neurons by intercellular signaling
por: Órdenes, P., et al.
Publicado: (2021)

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
por: Tooke, Benjamin P., et al.
Publicado: (2018)

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2
por: Windahl, Sara H, et al.
Publicado: (2013)

Relative Number and Distribution of Murine Hypothalamic Proopiomelanocortin Neurons Innervating Distinct Target Sites
por: King, Connie M., et al.
Publicado: (2011)

OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background
por: Gahlot, Surbhi, et al.
Publicado: (2020)

Correction to: Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone
por: Bergström, I., et al.
Publicado: (2018)

Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone
por: Bergström, I., et al.
Publicado: (2016)

Acute fat loss does not affect bone mass
por: Lagerquist, Marie K., et al.
Publicado: (2021)

Estrogen, astrocytes and the neuroendocrine control of metabolism
por: Fuente-Martin, E., et al.
Publicado: (2013)

aP2-Cre-Mediated Inactivation of Estrogen Receptor Alpha Causes Hydrometra
por: Antonson, Per, et al.
Publicado: (2014)

Obesity induced by estrogen deficiency is associated with hypothalamic inflammation
por: Yang, Hye Rim, et al.
Publicado: (2020)

Minireview: The Year in Review of Estrogen Regulation of Metabolism
por: Clegg, Deborah J.
Publicado: (2012)

Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice
por: Ramos-Pittol, Jose M., et al.
Publicado: (2023)

Olanzapine- induced metabolic syndrome pathogenesis: Hypothalamic “leptin resistance” or “pomc resistance”?
por: Veneziani, F., et al.
Publicado: (2021)

Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone
por: Todd, Henry, et al.
Publicado: (2015)

Clinically relevant doses of vitamin A decrease cortical bone mass in mice
por: Lionikaite, Vikte, et al.
Publicado: (2018)

Unraveling the Central Proopiomelanocortin Neural Circuits
por: Mercer, Aaron J., et al.
Publicado: (2013)

Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide
por: Besnier, E., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_phkla3h7hoju2ae0niratttk62