Cargando…

Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions

BACKGROUND: Covariation is an essential process that leads to coevolution of parts of proteins and genomes. In organisms subject to strong selective pressure, coevolution is central to keep the balance between the opposite requirements of antigenic variation and retention of functionality. Being the...

Descripción completa

Detalles Bibliográficos
Autores principales: Gasser, Romain, Hamoudi, Meriem, Pellicciotta, Martina, Zhou, Zhicheng, Visdeloup, Clara, Colin, Philippe, Braibant, Martine, Lagane, Bernard, Negroni, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967302/
https://www.ncbi.nlm.nih.gov/pubmed/27473399
http://dx.doi.org/10.1186/s12977-016-0285-6