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Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions
BACKGROUND: Covariation is an essential process that leads to coevolution of parts of proteins and genomes. In organisms subject to strong selective pressure, coevolution is central to keep the balance between the opposite requirements of antigenic variation and retention of functionality. Being the...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967302/ https://www.ncbi.nlm.nih.gov/pubmed/27473399 http://dx.doi.org/10.1186/s12977-016-0285-6 |