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The role of circulating thrombospondin-1 in patients with precapillary pulmonary hypertension

BACKGROUND: The vasoconstrictive protein TSP-1 is released from endothelial cells upon increased shear stress and hypoxia. Both conditions are prevalent in pulmonary hypertension (PH). TSP-1 damages the local microcirculation by disrupting pathways, which are essential for specific medical therapeut...

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Detalles Bibliográficos
Autores principales:	Kaiser, Ralf, Frantz, Christian, Bals, Robert, Wilkens, Heinrike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967340/ https://www.ncbi.nlm.nih.gov/pubmed/27473366 http://dx.doi.org/10.1186/s12931-016-0412-x

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