AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies

APS1/APECED patients are defined by defects in the autoimmune regulator (AIRE) that mediates central T cell tolerance to many self-antigens. AIRE deficiency also affects B cell tolerance, but this is incompletely understood. Here we show that most APS1/APECED patients displayed B cell autoreactivity...

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Detalles Bibliográficos
Autores principales: Meyer, Steffen, Woodward, Martin, Hertel, Christina, Vlaicu, Philip, Haque, Yasmin, Kärner, Jaanika, Macagno, Annalisa, Onuoha, Shimobi C., Fishman, Dmytro, Peterson, Hedi, Metsküla, Kaja, Uibo, Raivo, Jäntti, Kirsi, Hokynar, Kati, Wolff, Anette S.B., Krohn, Kai, Ranki, Annamari, Peterson, Pärt, Kisand, Kai, Hayday, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967814/
https://www.ncbi.nlm.nih.gov/pubmed/27426947
http://dx.doi.org/10.1016/j.cell.2016.06.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967814/
https://www.ncbi.nlm.nih.gov/pubmed/27426947
http://dx.doi.org/10.1016/j.cell.2016.06.024

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