A naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus–pituitary–adrenal axis activity early in ontogeny

We comprehensively characterized the effects of a unique natural gain-of-function mutation in the glucocorticoid receptor (GR), GR(Ala610Val), in domestic pigs to expand current knowledge of the phenotypic consequences of GR hypersensitivity. Cortisol levels were consistently reduced in one-week-old...

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Detalles Bibliográficos
Autores principales: Muráni, Eduard, Ponsuksili, Siriluck, Jaeger, Alexandra, Görres, Andreas, Tuchscherer, Armin, Wimmers, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967818/
https://www.ncbi.nlm.nih.gov/pubmed/27440422
http://dx.doi.org/10.1098/rsob.150193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967818/
https://www.ncbi.nlm.nih.gov/pubmed/27440422
http://dx.doi.org/10.1098/rsob.150193

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