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A naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus–pituitary–adrenal axis activity early in ontogeny

We comprehensively characterized the effects of a unique natural gain-of-function mutation in the glucocorticoid receptor (GR), GR(Ala610Val), in domestic pigs to expand current knowledge of the phenotypic consequences of GR hypersensitivity. Cortisol levels were consistently reduced in one-week-old...

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Detalles Bibliográficos
Autores principales:	Muráni, Eduard, Ponsuksili, Siriluck, Jaeger, Alexandra, Görres, Andreas, Tuchscherer, Armin, Wimmers, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967818/ https://www.ncbi.nlm.nih.gov/pubmed/27440422 http://dx.doi.org/10.1098/rsob.150193

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