Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication

Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely expla...

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Detalles Bibliográficos
Autores principales: Schulte, Tim, Liu, Lifeng, Panas, Marc D., Thaa, Bastian, Dickson, Nicole, Götte, Benjamin, Achour, Adnane, McInerney, Gerald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967826/
https://www.ncbi.nlm.nih.gov/pubmed/27383630
http://dx.doi.org/10.1098/rsob.160078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967826/
https://www.ncbi.nlm.nih.gov/pubmed/27383630
http://dx.doi.org/10.1098/rsob.160078

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