Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition

Cancer cells use precursors derived from tricarboxylic acid (TCA) cycle to support their unlimited growth. However, continuous export of TCA cycle intermediates results in the defect of mitochondrial integrity. Mitochondria glutamine metabolism plays an essential role for the maintenance of mitochon...

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Detalles Bibliográficos
Autores principales: Jeong, Seung Min, Hwang, Sunsook, Park, Kyungsoo, Yang, Seungyeon, Seong, Rho Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967856/
https://www.ncbi.nlm.nih.gov/pubmed/27477484
http://dx.doi.org/10.1038/srep30767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967856/
https://www.ncbi.nlm.nih.gov/pubmed/27477484
http://dx.doi.org/10.1038/srep30767

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