The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific

The apolipoprotein (apo) E4 isoform is the strongest risk factor for late-onset Alzheimer’s disease (AD). ApoE4 is more susceptible to proteolysis than apoE2 and apoE3 isoforms and carboxyl-terminal truncated apoE4 forms have been found in AD patients’ brain. We have previously shown that a specific...

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Detalles Bibliográficos
Autores principales: Dafnis, Ioannis, Argyri, Letta, Sagnou, Marina, Tzinia, Athina, Tsilibary, Effie C., Stratikos, Efstratios, Chroni, Angeliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967930/
https://www.ncbi.nlm.nih.gov/pubmed/27476701
http://dx.doi.org/10.1038/srep30654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967930/
https://www.ncbi.nlm.nih.gov/pubmed/27476701
http://dx.doi.org/10.1038/srep30654

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