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The use of CrossMAb technology for the generation of bi- and multispecific antibodies

The major challenge in the generation of bispecific IgG antibodies is enforcement of the correct heavy and light chain association. The correct association of generic light chains can be enabled using immunoglobulin domain crossover, known as CrossMAb technology, which can be combined with approache...

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Detalles Bibliográficos
Autores principales: Klein, Christian, Schaefer, Wolfgang, Regula, Jörg T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968094/
https://www.ncbi.nlm.nih.gov/pubmed/27285945
http://dx.doi.org/10.1080/19420862.2016.1197457