Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion

We have developed a mathematical framework for describing a bispecific monoclonal antibody interaction with two independent membrane-bound targets that are expressed on the same cell surface. The bispecific antibody in solution binds either of the two targets first, and then cross-links with the sec...

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Detalles Bibliográficos
Autores principales: Sengers, Bram G., McGinty, Sean, Nouri, Fatma Z., Argungu, Maryam, Hawkins, Emma, Hadji, Aymen, Weber, Andrew, Taylor, Adam, Sepp, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968105/
https://www.ncbi.nlm.nih.gov/pubmed/27097222
http://dx.doi.org/10.1080/19420862.2016.1178437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968105/
https://www.ncbi.nlm.nih.gov/pubmed/27097222
http://dx.doi.org/10.1080/19420862.2016.1178437

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