Structural diversity in a human antibody germline library

To support antibody therapeutic development, the crystal structures of a set of 16 germline variants composed of 4 different kappa light chains paired with 4 different heavy chains have been determined. All four heavy chains of the antigen-binding fragments (Fabs) have the same complementarity-deter...

Descripción completa

Detalles Bibliográficos
Autores principales: Teplyakov, Alexey, Obmolova, Galina, Malia, Thomas J., Luo, Jinquan, Muzammil, Salman, Sweet, Raymond, Almagro, Juan Carlos, Gilliland, Gary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968113/
https://www.ncbi.nlm.nih.gov/pubmed/27210805
http://dx.doi.org/10.1080/19420862.2016.1190060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968113/
https://www.ncbi.nlm.nih.gov/pubmed/27210805
http://dx.doi.org/10.1080/19420862.2016.1190060

Ejemplares similares