The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway

The most common genetic cause for amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) is repeat expansion of a hexanucleotide sequence (GGGGCC) within the C9orf72 genomic sequence. To elucidate the functional role of C9orf72 in disease pathogenesis, we identified certain molecular in...

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Detalles Bibliográficos
Autores principales: Ciura, Sorana, Sellier, Chantal, Campanari, Maria-Letizia, Charlet-Berguerand, Nicolas, Kabashi, Edor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968221/
https://www.ncbi.nlm.nih.gov/pubmed/27245636
http://dx.doi.org/10.1080/15548627.2016.1189070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968221/
https://www.ncbi.nlm.nih.gov/pubmed/27245636
http://dx.doi.org/10.1080/15548627.2016.1189070

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