Cargando…

Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7

As a selective degradation system, chaperone-mediated autophagy (CMA) is essential for maintaining cellular homeostasis and survival under stress conditions. Increasing evidence points to an important role for the dysfunction of CMA in the pathogenesis of Parkinson disease (PD). However, the mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Bao, Cai, Zhibiao, Tao, Kai, Zeng, Weijun, Lu, Fangfang, Yang, Ruixin, Feng, Dayun, Gao, Guodong, Yang, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Basic Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968227/ https://www.ncbi.nlm.nih.gov/pubmed/27171370 http://dx.doi.org/10.1080/15548627.2016.1179401

Ejemplares similares

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's Disease
por: Yang, Ruixin, et al.
Publicado: (2016)

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide
por: Macri, Christophe, et al.
Publicado: (2015)

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation
por: Qi, Lin, et al.
Publicado: (2012)

Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics
por: Nie, Tiejian, et al.
Publicado: (2020)

Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response
por: Zhu, Lin, et al.
Publicado: (2022)

6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway
por: Urano, Yasuomi, et al.
Publicado: (2018)

Internalized gap junctions are degraded by autophagy
por: Fong, John T., et al.
Publicado: (2012)

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation
por: Itakura, Eisuke, et al.
Publicado: (2016)

Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC
por: Cheramangalam, Rajit Narayanan, et al.
Publicado: (2023)

Dysregulation of autophagy and mitochondrial function in Parkinson’s disease
por: Wang, Bao, et al.
Publicado: (2016)

Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
por: Shen, Shensi, et al.
Publicado: (2009)

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
por: Kaushik, Susmita, et al.
Publicado: (2015)

Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
por: Park, Caroline, et al.
Publicado: (2015)

Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy
por: Jabir, Majid Sakhi, et al.
Publicado: (2015)

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
por: Xia, Hong-guang, et al.
Publicado: (2015)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A
por: Pajares, Marta, et al.
Publicado: (2018)

Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases
por: Devkota, Sushil, et al.
Publicado: (2016)

Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation
por: Liu, Yuan, et al.
Publicado: (2021)

Targeting mitochondrial degradation by chimeric autophagy-tethering compounds
por: Liu, Zhenqi, et al.
Publicado: (2023)

Inhibition of bromodomain-containing protein 4 enhances the migration of esophageal squamous cell carcinoma cells by inducing cell autophagy
por: Yang, Wen-Qian, et al.
Publicado: (2022)

A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates
por: Yefimova, Marina G., et al.
Publicado: (2013)

PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer
por: WANG, Yang, et al.
Publicado: (2015)

Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
por: Xia, Hong-guang, et al.
Publicado: (2016)

Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3
por: Yang, Yan-Hui, et al.
Publicado: (2019)

Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer
por: Yang, Yan-Hui, et al.
Publicado: (2017)

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life
por: Chun, Yoomi, et al.
Publicado: (2018)

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions
por: Deegan, Shane, et al.
Publicado: (2014)

BECN1 is involved in the initiation of mitophagy: It facilitates PARK2 translocation to mitochondria
por: Choubey, Vinay, et al.
Publicado: (2014)

Genistein-triggered anticancer activity against liver cancer cell line HepG2 involves ROS generation, mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of cell migration
por: Zhang, Qian, et al.
Publicado: (2018)

The Complex Role of Chaperone-Mediated Autophagy in Cancer Diseases
por: Liu, Jing, et al.
Publicado: (2023)

Chaperone-mediated autophagy: roles in neurodegeneration
por: Wang, Gang, et al.
Publicado: (2014)

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone
por: Currier, Rachel B., et al.
Publicado: (2019)

Chaperone mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation
por: Valdor, Rut, et al.
Publicado: (2014)

Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis
por: Napolitano, Gennaro, et al.
Publicado: (2015)

Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition
por: Tang, J, et al.
Publicado: (2017)

PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window
por: Shen, Zhe, et al.
Publicado: (2017)

Roles of molecular chaperones in protein degradation
Publicado: (1996)

Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy
por: Miao, You-Han, et al.
Publicado: (2021)

Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells
por: Zhang, Jia-Xiang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_87tv6sssp0dlrir4lb4ke8m3j1