Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations

BACKGROUND: The Mouse Genomes Project is an ongoing collaborative effort to sequence the genomes of the common laboratory mouse strains. In 2011, the initial analysis of sequence variation across 17 strains found 56.7 M unique single nucleotide polymorphisms (SNPs) and 8.8 M indels. We carry out dee...

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Detalles Bibliográficos
Autores principales: Doran, Anthony G., Wong, Kim, Flint, Jonathan, Adams, David J., Hunter, Kent W., Keane, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968449/
https://www.ncbi.nlm.nih.gov/pubmed/27480531
http://dx.doi.org/10.1186/s13059-016-1024-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968449/
https://www.ncbi.nlm.nih.gov/pubmed/27480531
http://dx.doi.org/10.1186/s13059-016-1024-y

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