Cargando…

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography

PURPOSE: Spectral-domain optical coherence tomography (SD-OCT) was used to characterize the retinal phenotype, natural history, and treatment responses in a mouse model of X-linked retinoschisis (Rs1-KO) and to identify new structural markers of AAV8-mediated gene therapy outcome. METHODS: Optical c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Yong, Petralia, Ronald S., Vijayasarathy, Camasamudram, Wu, Zhijian, Hiriyanna, Suja, Song, Hongman, Wang, Ya-Xian, Sieving, Paul A., Bush, Ronald A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968785/ https://www.ncbi.nlm.nih.gov/pubmed/27409484 http://dx.doi.org/10.1167/iovs.15-18920

Ejemplares similares

Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina
por: Heymann, J. Bernard, et al.
Publicado: (2019)

Targeted Expression of Retinoschisin by Retinal Bipolar Cells in XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1 From Photoreceptors
por: Vijayasarathy, Camasamudram, et al.
Publicado: (2022)

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice
por: Song, Hongman, et al.
Publicado: (2016)

Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice
por: Marangoni, Dario, et al.
Publicado: (2016)

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration
por: Song, Hongman, et al.
Publicado: (2020)

Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome
por: Marangoni, Dario, et al.
Publicado: (2017)

Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration
por: Song, Hongman, et al.
Publicado: (2018)

Genetic Rescue of X-Linked Retinoschisis Mouse (Rs1(−/y)) Retina Induces Quiescence of the Retinal Microglial Inflammatory State Following AAV8-RS1 Gene Transfer and Identifies Gene Networks Underlying Retinal Recovery
por: Vijayasarathy, Camasamudram, et al.
Publicado: (2021)

Retinal Imaging of Infants on Spectral Domain Optical Coherence Tomography
por: Vinekar, Anand, et al.
Publicado: (2015)

Retinoschisin is linked to retinal Na/K-ATPase signaling and localization
por: Plössl, Karolina, et al.
Publicado: (2017)

Identification of the retinoschisin-binding site on the retinal Na/K-ATPase
por: Plössl, Karolina, et al.
Publicado: (2019)

Retinoschisin and Cardiac Glycoside Crosstalk at the Retinal Na/K-ATPase
por: Schmid, Verena, et al.
Publicado: (2020)

Progression of transsynaptic retinal degeneration with spectral-domain optical coherence tomography
por: Schwartz, Stephen G., et al.
Publicado: (2016)

Clinical applications of spectral domain optical coherence tomography in retinal diseases
por: Murthy, R.K., et al.
Publicado: (2016)

Spectral-domain optical coherence tomography characteristics of cystic retinal tuft
por: Li, Haidong, et al.
Publicado: (2022)

Detection of retinal changes in Parkinson’s disease with spectral-domain optical coherence tomography
por: Aaker, Grant D, et al.
Publicado: (2010)

Retinal Neurodegeneration in Wilson’s Disease Revealed by Spectral Domain Optical Coherence Tomography
por: Albrecht, Philipp, et al.
Publicado: (2012)

The potential of spectral domain optical coherence tomography imaging based retinal biomarkers
por: Phadikar, Prateep, et al.
Publicado: (2017)

SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN MACULA-INVOLVING CYTOMEGALOVIRUS RETINITIS
por: Gupta, Mrinali P., et al.
Publicado: (2018)

Spectral-domain optical coherence tomography finding of acute retinal pigment epitheliitis
por: Li, Yi-Hsuan, et al.
Publicado: (2019)

Rs1h(−/y) exon 3-del rat model of X-linked retinoschisis with early onset and rapid phenotype is rescued by RS1 supplementation
por: Zeng, Yong, et al.
Publicado: (2021)

Retinal Nerve Fiber Layer Measurement Variability with Spectral Domain Optical Coherence Tomography
por: Hong, Jung Taeck, et al.
Publicado: (2012)

Automated segmentation of retinal blood vessels in spectral domain optical coherence tomography scans
por: Pilch, Matthäus, et al.
Publicado: (2012)

Spectral-domain optical coherence tomography imaging of macula-off rhegmatogenous retinal detachment
por: Sridhar, Jayanth, et al.
Publicado: (2014)

Early Retinal Changes in Hunter Syndrome According to Spectral Domain Optical Coherence Tomography
por: Kim, Seonghwan, et al.
Publicado: (2016)

Volume Averaging of Spectral-Domain Optical Coherence Tomography Impacts Retinal Segmentation in Children
por: Trimboli-Heidler, Carmelina, et al.
Publicado: (2016)

Quantifying microstructural changes in retinitis pigmentosa using spectral domain – optical coherence tomography
por: Poornachandra, B., et al.
Publicado: (2019)

A Case of Retinal Cavernous Hemangioma Diagnosed with Spectral Domain Optical Coherence Tomography
por: Cho, Kyuyeon, et al.
Publicado: (2017)

Inner and Outer Retinal Volumetric and Morphologic Analysis of the Macula with Spectral Domain Optical Coherence Tomography in Retinitis Pigmentosa
por: Sheth, Saumil S., et al.
Publicado: (2012)

Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer
por: Zhang, Xiangyang, et al.
Publicado: (2011)

Age and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography
por: Lee, Jong Yeon, et al.
Publicado: (2012)

Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography
por: Khanifar, Aziz A, et al.
Publicado: (2010)

Spectral-domain Optical Coherence Tomography of Combined Hamartoma of the Retina and Retinal Pigment Epithelium in Neurofibromatosis
por: Kang, Hae Min, et al.
Publicado: (2013)

Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine
por: Ulviye, Yigit, et al.
Publicado: (2013)

Spectral domain optical coherence tomography imaging of subretinal bands associated with chronic retinal detachments
por: Kothari, Nikisha, et al.
Publicado: (2016)

Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical Coherence Tomography
por: Chen, Binyao, et al.
Publicado: (2016)

Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography
por: Uslu, Hasim, et al.
Publicado: (2016)

Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography
por: Koulisis, Nicole, et al.
Publicado: (2017)

Spectral-Domain Optical Coherence Tomography for Macular Edema
por: Badaró, Emmerson, et al.
Publicado: (2014)

Spectral-Domain Optical Coherence Tomography for Glaucoma Diagnosis
por: Gracitelli, Carolina P.B, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_btjcqhtqp8l2u20seisjetmjoa