Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma

Deficiency of methylthioadenosine phosphorylase (MTAP) supports melanoma development and progression through accumulation of its substrate 5’-methylthioadenosine (MTA), which leads amongst others to a constitutive inhibition of protein arginine methyltransferases (PRMTs) and activation of the transc...

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Detalles Bibliográficos
Autores principales: Limm, Katharina, Dettmer, Katja, Reinders, Jörg, Oefner, Peter J., Bosserhoff, Anja-Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968798/
https://www.ncbi.nlm.nih.gov/pubmed/27479139
http://dx.doi.org/10.1371/journal.pone.0160348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968798/
https://www.ncbi.nlm.nih.gov/pubmed/27479139
http://dx.doi.org/10.1371/journal.pone.0160348

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