Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch

Lysine-specific histone demethylase 1 (LSD1) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells (iPSCs). Here we reported that LSD1 inhibition via shRNA or specific inhibitor, tranylcypromine, promoted reprogramming at e...

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Detalles Bibliográficos
Autores principales: Sun, Hao, Liang, Lining, Li, Yuan, Feng, Chengqian, Li, Lingyu, Zhang, Yixin, He, Songwei, Pei, Duanqing, Guo, Yunqian, Zheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969595/
https://www.ncbi.nlm.nih.gov/pubmed/27481483
http://dx.doi.org/10.1038/srep30903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969595/
https://www.ncbi.nlm.nih.gov/pubmed/27481483
http://dx.doi.org/10.1038/srep30903

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